Efficacy of a Novel Intra-Articular Administration of Platelet-Rich Plasma One-Week Prior to Hyaluronic Acid versus Platelet-Rich Plasma Alone in Knee Osteoarthritis: A Prospective, Randomized, Double-Blind, Controlled Trial

Osteoarthritis of the knee is a chronic degenerative disorder associated with the progressive breakdown of the articular cartilage in synovial joints, accompanied by the development of osteophytes, subchondral sclerosis, and cyst formation. It is the most common joint disease, with an annual incidence of 4.7% to 6.0%, and it is more common in female individuals than in male individuals (as high as 4:1) [1–3]. Furthermore, the impact of sex is more noticeable over the age of 50 years because the risk among female and male individuals is similar before the age of 50 years [4]. The clinical manifestations of knee osteoarthritis include pain, stiffness, effusion, deformity of the knee, and progressive limitation while performing daily activities. The prevalence of knee osteoarthritis is growing, and its consequences have a debilitating effect on the quality of life.

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